Pulmonary Medication Delivery
When nebulized medications are delivered to intubated patients most drug (95 to 97%) is lost into the external environment or adhered to the wall of the ventilation circuit or endotracheal tube. To overcome this problem, a device that is threaded down the endotracheal tube and provides synchronized drug atomization/nebulization with the inhalation cycle will result in far higher drug levels delivered to the pulmonary tissue.
The MADett accomplishes this easily. It attaches directly to the endotracheal tube and the ventilator circuit (or ventilation bag) so that ongoing ventilation is possible while the device is attached. The MADett catheter is then advanced down the ETT to be fixed at the distal tip of the tube. An appropriate drug in a syringe is then attached to the proximal luer adapter of the MADett device. Compression of the syringe during inhalation results in a fine atomized mist that is entrained in the airflow and delivered distally to the bronchioles and alveolar tissue.